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Details on Person PDGFRA, PDGFRB [plasma membrane]

Class:Id	DefinedSet:186792
_displayName	PDGFRA, PDGFRB [plasma membrane]
_timestamp	2020-01-10 04:13:37
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
hasMember	[EntityWithAccessionedSequence:186794] PDGFRA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:186767] PDGFRB [plasma membrane] [Homo sapiens]
modified	[InstanceEdit:9674081] Rothfels, Karen, 2020-01-10
name	PDGFRA, PDGFRB
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:399640] R-HSA-186792.2
(hasComponent)	[Complex:9674086] PDGFR:type II PDGFR-binding TKIs [plasma membrane] [Homo sapiens]
(input)	[BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:9674095] PDGFRs bind type II TKI [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9672155] gain_of_function of PDGFR mutant receptors [plasma membrane] [EntityFunctionalStatus:9674394] loss_of_function of imatinib-resistant PDGFR mutants [plasma membrane] [EntityFunctionalStatus:9674399] loss_of_function of regorafenib-resistant PDGFR mutants [plasma membrane] [EntityFunctionalStatus:9674402] loss_of_function of sorafenib-resistant PDGFR mutants [plasma membrane] [EntityFunctionalStatus:9674406] loss_of_function of PDGFRA D842V [plasma membrane] [EntityFunctionalStatus:9674448] gain_of_function of type II TKI sensitive PDGFR mutants [plasma membrane]
(updatedInstance)	[_UpdateTracker:9901128] Update Tracker - [DefinedSet:186792] PDGFRA, PDGFRB [plasma membrane] - v72:[modifyName]
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No pathways have been reviewed or authored by PDGFRA, PDGFRB [plasma membrane] (186792)