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Details on Person Receptor dimerisation is key event in PDGF receptor activati...
| Class:Id | Summation:186790 |
|---|---|
| _displayName | Receptor dimerisation is key event in PDGF receptor activati... |
| _timestamp | 2020-02-07 19:04:02 |
| created | [InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10 |
| literatureReference | [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors |
| modified | [InstanceEdit:389055] Garapati, P V, 2008-12-19 10:22:03 [InstanceEdit:389093] Garapati, P V, 2008-12-19 13:01:58 [InstanceEdit:9674472] Rothfels, Karen, 2020-01-13 [InstanceEdit:9674505] Rothfels, Karen, 2020-01-13 [InstanceEdit:9676111] Rothfels, Karen, 2020-02-07 |
| text | Receptor dimerisation is key event in PDGF receptor activation. The intracellular regions of the receptors are juxtaposed which allows trans-phosphorylation between the two receptors in the complex. The autophosphorylation site Y857 located inside the kinase domain of beta-receptor (PDGFRB) is important for activation of the kinase. This tyrosine is conserved in the alpha-receptor (PDGFRA), where it corresponsds to Y849, and in almost all other tyrosine kinase receptors. The other known autophosphorylation sites are localized outside the kinase domains of the alpha- and beta- receptors; of the 15( beta) or 16 (alpha) tyrosine residues in the intracellular, non-catalytic part of the beta- or alpha receptor, 11 and 10, respectively, are autophosphorylation sites (reviewed in Heldin et al, 1998). PDGFRA and PDGFRB activity can be inhibited by binding to type I and type II tyrosine kinase inhibitors (reviewed in Roskoski, 2018). Type I inhibitors such as crenolanib, avripatinib and pazopanib, bind to the active conformation of the receptor and inhibit trans-autophosphorylation (Ip et al, 2018; Evans et al, 2017; Davids et al, 2009; reviewed in Roskoski, 2018; Klug et al, 2018; Papadopoulos and Lennartsson, 2016). |
| (summation) | [Reaction:186786] Autophosphorylation of PDGF beta receptors [Homo sapiens] [Reaction:389083] Autophosphorylation of PDGF alpha receptors [Homo sapiens] [Reaction:389086] Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] |
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