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Details on Person PDGF-AA clevage by Furin

Class:IdReaction:186785
_displayNamePDGF-AA clevage by Furin
_doReleaseTRUE
_timestamp2016-03-21 17:14:49
authored[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
catalystActivity[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
compartment[Compartment:984] extracellular region
[Compartment:20699] Golgi membrane
created[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
edited[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
input[Complex:380749] proPDGF-AA dimer [Golgi membrane] [Homo sapiens]
literatureReference[LiteratureReference:380776] PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly
[LiteratureReference:380726] The PDGF family: four gene products form five dimeric isoforms
[LiteratureReference:380730] Mechanism of action and in vivo role of platelet-derived growth factor
modified[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:380783] Garapati, P V, 2008-11-14 10:48:40
[InstanceEdit:382063] Garapati, P V, 2008-11-21 20:22:15
[InstanceEdit:382622] Garapati, P V, 2008-11-24 00:32:38
[InstanceEdit:382630] Garapati, P V, 2008-11-24 10:24:16
[InstanceEdit:389087] Garapati, P V, 2008-12-19 10:29:26
[InstanceEdit:392248] Garapati, P V, 2009-03-01 16:05:31
[InstanceEdit:397770] Garapati, P V, 2009-03-11 16:17:12
[InstanceEdit:398093] Garapati, P V, 2009-03-16 16:45:20
[InstanceEdit:398096] Garapati, P V, 2009-03-16 17:00:58
[InstanceEdit:2648974] D'Eustachio, P, 2012-11-21
[InstanceEdit:8865209] Garapati, Phani Vijay, 2016-03-21
[InstanceEdit:8865277] Garapati, Phani Vijay, 2016-03-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePDGF-AA clevage by Furin
output[Complex:380761] active PDGF-AA dimer [extracellular region] [Homo sapiens]
[DefinedSet:8865271] N-ter PDGF-A fragment [Golgi lumen] [Homo sapiens]
[DefinedSet:8865271] N-ter PDGF-A fragment [Golgi lumen] [Homo sapiens]
precedingEvent
releaseDate2009-04-01
reviewed[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:398488] R-HSA-186785.3
summation[Summation:380728] After dimerization of the PDGF-A and PDGF-B chains in the ER...
(hasEvent)[Pathway:186797] Signaling by PDGF [Homo sapiens]
(precedingEvent)[BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens]
[Reaction:382054] PDGF binds to extracellular matrix proteins [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783147] Update Tracker - [Reaction:186785] PDGF-AA clevage by Furin - v57:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by PDGF-AA clevage by Furin (186785)
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