Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PI3-kinase binds to the active receptor

Class:Id	Reaction:186780
_displayName	PI3-kinase binds to the active receptor
_doRelease	TRUE
_timestamp	2024-03-20 22:11:37
authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
input	[Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] [Homo sapiens] [Complex:74693] PI3K [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:381866] Role of phosphatidylinositol kinase in PDGF receptor signal transduction [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:382017] Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
modified	[InstanceEdit:382063] Garapati, P V, 2008-11-21 20:22:15 [InstanceEdit:382621] Garapati, P V, 2008-11-24 00:31:49 [InstanceEdit:382629] Garapati, P V, 2008-11-24 10:23:46 [InstanceEdit:389087] Garapati, P V, 2008-12-19 10:29:26 [InstanceEdit:392248] Garapati, P V, 2009-03-01 16:05:31 [InstanceEdit:398091] Garapati, P V, 2009-03-16 16:42:15 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865978] Orlic-Milacic, Marija, 2024-03-20
name	PI3-kinase binds to the active receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865972] Futile Cycle: Activated PLC gamma dissociates from the PDGF receptor
output	[Complex:186789] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:186786] Autophosphorylation of PDGF beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389083] Autophosphorylation of PDGF alpha receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389086] Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398481] R-HSA-186780.3
summation	[Summation:186784] Phosphatidylinositol 3'-kinases (PI3Ks) are a family of enzy...
(hasEvent)	[Pathway:186763] Downstream signal transduction [Homo sapiens]
(normalReaction)	[Reaction:9672172] PI3-kinase binds to mutant PDGFR receptor [Homo sapiens]
(precedingEvent)	[Reaction:186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777374] Update Tracker - [Reaction:186780] PI3-kinase binds to the active receptor - v72:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by PI3-kinase binds to the active receptor (186780)