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Details on Person SHP2 binds to the active receptor

Class:Id	Reaction:186778
_displayName	SHP2 binds to the active receptor
_doRelease	TRUE
_timestamp	2024-03-20 22:11:49
authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
input	[Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:381875] Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors
modified	[InstanceEdit:186838] Jassal, B, 2006-08-24 13:02:57 [InstanceEdit:382063] Garapati, P V, 2008-11-21 20:22:15 [InstanceEdit:382623] Garapati, P V, 2008-11-24 00:33:18 [InstanceEdit:382631] Garapati, P V, 2008-11-24 10:24:46 [InstanceEdit:389087] Garapati, P V, 2008-12-19 10:29:26 [InstanceEdit:392248] Garapati, P V, 2009-03-01 16:05:31 [InstanceEdit:398091] Garapati, P V, 2009-03-16 16:42:15 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865978] Orlic-Milacic, Marija, 2024-03-20
name	SHP2 binds to the active receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865968] Futile Cycle: Activated PLC gamma dissociates from the PDGF receptor
output	[Complex:186839] PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:186786] Autophosphorylation of PDGF beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389083] Autophosphorylation of PDGF alpha receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389086] Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398389] R-HSA-186778.3
summation	[Summation:186836] Protein-tyrosine phosphatase 2C (SHP2) is ubiquitously expre...
(hasEvent)	[Pathway:186763] Downstream signal transduction [Homo sapiens]
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