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Details on Person PLC-gamma binds to the active receptor

Class:Id	Reaction:186765
_displayName	PLC-gamma binds to the active receptor
_doRelease	TRUE
_timestamp	2024-03-20 22:11:41
authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
input	[Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:167682] PLCG1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:381858] Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:382010] Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1
modified	[InstanceEdit:186838] Jassal, B, 2006-08-24 13:02:57 [InstanceEdit:382063] Garapati, P V, 2008-11-21 20:22:15 [InstanceEdit:382621] Garapati, P V, 2008-11-24 00:31:49 [InstanceEdit:382630] Garapati, P V, 2008-11-24 10:24:16 [InstanceEdit:389087] Garapati, P V, 2008-12-19 10:29:26 [InstanceEdit:392248] Garapati, P V, 2009-03-01 16:05:31 [InstanceEdit:398091] Garapati, P V, 2009-03-16 16:42:15 [InstanceEdit:3632848] Jupe, S, 2013-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865978] Orlic-Milacic, Marija, 2024-03-20
name	PLC-gamma binds to the active receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865974] Futile Cycle: Activated PLC gamma dissociates from the PDGF receptor
output	[Complex:186795] PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:186786] Autophosphorylation of PDGF beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389083] Autophosphorylation of PDGF alpha receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389086] Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398427] R-HSA-186765.3
summation	[Summation:186840] PLC-gamma 1 has been shown to bind to phosphorylated Tyr 102...
(hasEvent)	[Pathway:186763] Downstream signal transduction [Homo sapiens]
(precedingEvent)	[Reaction:1524186] Phosphorylation of PLCgamma by PDGFR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787420] Update Tracker - [Reaction:186765] PLC-gamma binds to the active receptor - v45:[add_removeInput]
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