Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein

Class:IdBlackBoxEvent:186535
_displayNameMafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
_doReleaseTRUE
_timestamp2016-03-03 20:56:14
authored[InstanceEdit:351500] Ferrer, J, Tello-Ruiz, MK, 2008-05-23
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:186665] Tello-Ruiz, MK, 2006-08-14 15:25:20
edited[InstanceEdit:190295] Tello-Ruiz, MK, 2006-12-19 19:02:30
literatureReference[LiteratureReference:187350] Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells
[LiteratureReference:187371] Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
[LiteratureReference:189541] MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene
[LiteratureReference:187478] Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
[LiteratureReference:187269] Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.
[LiteratureReference:187476] Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
[LiteratureReference:189588] Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
[LiteratureReference:186720] Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.
[LiteratureReference:186688] IPF1, a homeodomain-containing transactivator of the insulin gene
[LiteratureReference:186519] beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
modified[InstanceEdit:187098] Tello-Ruiz, MK, 2006-09-08 18:39:34
[InstanceEdit:187191] Tello-Ruiz, MK, 2006-09-08 22:11:04
[InstanceEdit:187248] Tello-Ruiz, MK, 2006-09-11 23:46:47
[InstanceEdit:187302] Tello-Ruiz, MK, 2006-09-13 01:14:23
[InstanceEdit:187343] Tello-Ruiz, MK, 2006-09-13 18:21:59
[InstanceEdit:189125] Tello-Ruiz, MK, 2006-11-03 15:56:51
[InstanceEdit:189535] Tello-Ruiz, MK, 2006-11-27 21:00:31
[InstanceEdit:189794] Tello-Ruiz, MK, 2006-12-01 23:20:56
[InstanceEdit:190279] Tello-Ruiz, MK, 2006-12-18 20:27:37
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:349416] D'Eustachio, P, 2008-05-07 20:42:40
[InstanceEdit:349684] D'Eustachio, P, 2008-05-12 21:51:33
[InstanceEdit:350214] D'Eustachio, P, 2008-05-14 17:51:53
[InstanceEdit:351498] D'Eustachio, P, 2008-05-23 22:55:12
[InstanceEdit:2671770] D'Eustachio, P, 2012-11-25
[InstanceEdit:8863057] D'Eustachio, Peter, 2016-03-03
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
output[EntityWithAccessionedSequence:189777] Ins1 [cytosol] [Mus musculus]
regulatedBy[PositiveRegulation:189707] Positive regulation by 'MafA [nucleoplasm]'
[PositiveRegulation:189712] Positive regulation by 'ipf1/pdx1 [nucleoplasm]'
[PositiveRegulation:189739] Positive regulation by 'nkx2.2 [nucleoplasm]'
[PositiveRegulation:189791] Positive regulation by 'Pax6 [nucleoplasm]'
releaseDate2008-06-30
reviewed[InstanceEdit:349683] Jensen, J, 2008-05-12 21:46:53
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:358744] R-MMU-186535.4
summation[Summation:187348] Human and mouse MafA/RIPE3b1 bind to the insulin promoter in...
(inferredFrom)[BlackBoxEvent:211289] MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein [Homo sapiens]
(replacementInstances)[_Deleted:8863058] Deletion of instance: 186710
[_Deleted:8863059] Deletion of instance: 186468
[_Deleted:8863060] Deletion of instance: 186479
(updatedInstance)[_UpdateTracker:9783208] Update Tracker - [BlackBoxEvent:186535] MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein - v57:[addLiteratureReference, addRegulator, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (186535)
Follow Reactome