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Details on Person NeuroD1- and Pdx1-dependent synthesis of glucokinase (Gck) protein

Class:Id	BlackBoxEvent:186510
_displayName	NeuroD1- and Pdx1-dependent synthesis of glucokinase (Gck) protein
_doRelease	TRUE
_timestamp	2016-03-03 22:04:05
authored	[InstanceEdit:351500] Ferrer, J, Tello-Ruiz, MK, 2008-05-23
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:186665] Tello-Ruiz, MK, 2006-08-14 15:25:20
edited	[InstanceEdit:190295] Tello-Ruiz, MK, 2006-12-19 19:02:30
literatureReference	[LiteratureReference:187472] BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells [LiteratureReference:187269] Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. [LiteratureReference:186720] Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. [LiteratureReference:187315] The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells
modified	[InstanceEdit:187098] Tello-Ruiz, MK, 2006-09-08 18:39:34 [InstanceEdit:187191] Tello-Ruiz, MK, 2006-09-08 22:11:04 [InstanceEdit:187248] Tello-Ruiz, MK, 2006-09-11 23:46:47 [InstanceEdit:187302] Tello-Ruiz, MK, 2006-09-13 01:14:23 [InstanceEdit:187471] Tello-Ruiz, MK, 2006-09-14 22:42:08 [InstanceEdit:189125] Tello-Ruiz, MK, 2006-11-03 15:56:51 [InstanceEdit:189535] Tello-Ruiz, MK, 2006-11-27 21:00:31 [InstanceEdit:189794] Tello-Ruiz, MK, 2006-12-01 23:20:56 [InstanceEdit:190279] Tello-Ruiz, MK, 2006-12-18 20:27:37 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:211351] D'Eustachio, P, 2008-02-01 22:29:46 [InstanceEdit:349416] D'Eustachio, P, 2008-05-07 20:42:40 [InstanceEdit:349684] D'Eustachio, P, 2008-05-12 21:51:33 [InstanceEdit:350214] D'Eustachio, P, 2008-05-14 17:51:53 [InstanceEdit:351498] D'Eustachio, P, 2008-05-23 22:55:12 [InstanceEdit:2671770] D'Eustachio, P, 2012-11-25 [InstanceEdit:8863071] D'Eustachio, Peter, 2016-03-03 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NeuroD1- and Pdx1-dependent synthesis of glucokinase (Gck) protein
output	[DefinedSet:211356] Glucokinase [cytosol] [Mus musculus]
regulatedBy	[PositiveRegulation:189728] Positive regulation by 'ipf1/pdx1 [nucleoplasm]' [PositiveRegulation:189741] Positive regulation by 'NeuroD1 [nucleoplasm]'
releaseDate	2008-06-30
reviewed	[InstanceEdit:349683] Jensen, J, 2008-05-12 21:46:53
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:360958] R-MMU-186510.4
summation	[Summation:186522] NeuroD1 binds to control sequences of the mouse GK gene in v...
(inferredFrom)	[BlackBoxEvent:211346] NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein [Homo sapiens]
(replacementInstances)	[_Deleted:8863072] Deletion of instance: 186588
(updatedInstance)	[_UpdateTracker:9783245] Update Tracker - [BlackBoxEvent:186510] NeuroD1- and Pdx1-dependent synthesis of glucokinase (Gck) protein - v57:[addLiteratureReference, addRegulator, modifyText]
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