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Details on Person GBA2 hydrolyzes GlcCer (plasma membrane)

Class:Id	Reaction:1861788
_displayName	GBA2 hydrolyzes GlcCer (plasma membrane)
_doRelease	TRUE
_timestamp	2023-08-11 10:47:51
authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1861763] glucosylceramidase activity of GBA2 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1861756] Jassal, B, 2011-10-31
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
input	[SimpleEntity:1861782] GlcCer [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1861775] Molecular cloning and expression of human bile acid beta-glucosidase [LiteratureReference:1861759] Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2
modified	[InstanceEdit:1863069] Jassal, Bijay, 2011-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841226] Stephan, Ralf, 2023-08-11
name	GBA2 hydrolyzes GlcCer (plasma membrane)
output	[SimpleEntity:429807] CERA [plasma membrane] [SimpleEntity:70113] Glc [cytosol]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016290] R-HSA-1861788.3
summation	[Summation:1861767] Human glucosylceramidase 2 (GBA2) hydrolyzes the glucosidic ...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(precedingEvent)	[Reaction:429786] SGMS2 transfers phosphocholine onto ceramide [Homo sapiens] [Reaction:1606583] ASAH2 hydrolyzes ceramide (plasma membrane) [Homo sapiens] [Reaction:1638845] CERK phosphorylates CERA to form C1P [Homo sapiens] [Reaction:6785933] UGT8 transfers Gal from UDP-Gal to CERA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9842274] Update Tracker - [Reaction:1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - v86:[modifyText]
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