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Details on Person I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol

Class:Id	Reaction:1855223
_displayName	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
_doRelease	TRUE
_timestamp	2016-11-10 00:55:59
authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023967] inositol-1,3,4,5,6-pentakisphosphate kinase activity of IP6K1/3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
input	[SimpleEntity:994141] I(1,3,4,5,6)P5 [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1889803] Identification and characterization of a novel inositol hexakisphosphate kinase [LiteratureReference:1889872] The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis [LiteratureReference:1889876] Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups
modified	[InstanceEdit:1884039] Williams, MG, 2011-10-31 [InstanceEdit:1889946] Williams, MG, 2011-11-01 [InstanceEdit:2023980] Williams, MG, 2011-12-13 [InstanceEdit:2562613] D'Eustachio, P, 2012-11-06 [InstanceEdit:2564838] D'Eustachio, P, 2012-11-07 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
output	[SimpleEntity:1629755] 5-PP-IP4 [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1855161] I(1,3,4,5,6)P5 transports from the nucleus to the cytosol [Homo sapiens] [BlackBoxEvent:1855160] I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus [Homo sapiens] [Reaction:1855206] I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus [Homo sapiens] [Reaction:1855228] I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus [Homo sapiens] [Reaction:1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus [Homo sapiens] [Reaction:1855162] I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855219] I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855166] PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol [Homo sapiens] [Reaction:1855173] 5-PP-IP4 transports from the nucleus to the cytosol [Homo sapiens] [Reaction:1855223] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol [Homo sapiens] [Reaction:1855155] I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol [Homo sapiens] [Reaction:1855195] I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen [Homo sapiens] [Reaction:1855225] IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200197] R-HSA-1855223.3
summation	[Summation:2023978] Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) pho...
(hasEvent)	[Pathway:1855167] Synthesis of pyrophosphates in the cytosol [Homo sapiens]
(precedingEvent)	[Reaction:1855166] PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol [Homo sapiens] [Reaction:1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol [Homo sapiens]
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