Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol

Class:Id	Reaction:1855218
_displayName	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
_doRelease	TRUE
_timestamp	2025-09-21 08:59:01
authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023846] inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of INPP5(3)/ITPK1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:9966359] RHEA:11393
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
input	[SimpleEntity:994170] I(1,3,4,5)P4 [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1889864] Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase [LiteratureReference:1889850] Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation [LiteratureReference:1889896] The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase [LiteratureReference:1675778] Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase [LiteratureReference:1889935] Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2 [LiteratureReference:1676110] Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 [LiteratureReference:1675871] Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles [LiteratureReference:1675891] The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase [LiteratureReference:1889910] Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate
modified	[InstanceEdit:1884039] Williams, MG, 2011-10-31 [InstanceEdit:1889946] Williams, MG, 2011-11-01 [InstanceEdit:2023872] Williams, MG, 2011-12-13 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966360] Stephan, Ralf, 2025-09-21
name	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
output	[SimpleEntity:994123] I(1,3,4)P3 [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane [Homo sapiens] [Reaction:1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol [Homo sapiens] [Reaction:1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol [Homo sapiens] [Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens] [Reaction:1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol [Homo sapiens] [Reaction:1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane [Homo sapiens] [Reaction:1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol [Homo sapiens]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200155] R-HSA-1855218.4
summation	[Summation:2023884] A group of inositol phosphatases and the broad specificity e...
(hasEvent)	[Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol [Homo sapiens]
(precedingEvent)	[Reaction:1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855180] I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol [Homo sapiens] [Reaction:1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855232] I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (1855218)