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Details on Person I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

Class:Id	Reaction:1855205
_displayName	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
_doRelease	TRUE
_timestamp	2025-09-21 08:59:11
authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023851] inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity of PTEN:Mg2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:9966356] RHEA:77156
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
input	[SimpleEntity:994170] I(1,3,4,5)P4 [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:199432] The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate [LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay
modified	[InstanceEdit:1884039] Williams, MG, 2011-10-31 [InstanceEdit:1889946] Williams, MG, 2011-11-01 [InstanceEdit:2023872] Williams, MG, 2011-12-13 [InstanceEdit:2240987] D'Eustachio, P, 2012-05-08 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966360] Stephan, Ralf, 2025-09-21
name	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
output	[SimpleEntity:114520] I(1,4,5)P3 [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane [Homo sapiens] [Reaction:1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol [Homo sapiens] [Reaction:1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol [Homo sapiens] [Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens] [Reaction:1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol [Homo sapiens] [Reaction:1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane [Homo sapiens] [Reaction:1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol [Homo sapiens]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200257] R-HSA-1855205.4
summation	[Summation:2023854] Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and d...
(hasEvent)	[Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol [Homo sapiens]
(precedingEvent)	[Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Homo sapiens] [Reaction:1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol [Homo sapiens] [Reaction:1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol [Homo sapiens] [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus [Homo sapiens] [Reaction:1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane [Homo sapiens]
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