Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
Class:Id Reaction:1855201 _displayName I(1,3,4,6)P4 transports from the cytosol to the nucleus _doRelease TRUE _timestamp 2025-12-16 21:52:45 authored [InstanceEdit:1855226] Williams, MG, 2011-10-28 catalystActivity [CatalystActivity:9954155] narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope] compartment [Compartment:70101] cytosol [Compartment:7660] nucleoplasm created [InstanceEdit:1855226] Williams, MG, 2011-10-28 edited [InstanceEdit:1855226] Williams, MG, 2011-10-28 goBiologicalProcess [GO_BiologicalProcess:160267] import into nucleus input [SimpleEntity:994146] I(1,3,4,6)P4 [cytosol] internalReviewed [InstanceEdit:9968056] D'Eustachio, Peter, 2025-10-08 [InstanceEdit:9977081] D'Eustachio, Peter, 2025-12-16 isChimeric FALSE literatureReference [LiteratureReference:1889864] Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase [LiteratureReference:1889919] The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization modified [InstanceEdit:1884039] Williams, MG, 2011-10-31 [InstanceEdit:1889946] Williams, MG, 2011-11-01 [InstanceEdit:2023905] Williams, MG, 2011-12-13 [InstanceEdit:2562613] D'Eustachio, P, 2012-11-06 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9954157] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9954161] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13 [InstanceEdit:9968055] D'Eustachio, Peter, 2025-10-08 [InstanceEdit:9968057] D'Eustachio, Peter, 2025-10-08 [InstanceEdit:9968060] D'Eustachio, Peter, 2025-10-08 [InstanceEdit:9977080] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977082] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977085] D'Eustachio, Peter, 2025-12-16 name I(1,3,4,6)P4 transports from the cytosol to the nucleus output [SimpleEntity:2023892] I(1,3,4,6)P4 [nucleoplasm] precedingEvent [Reaction:1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol [Homo sapiens] [Reaction:1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane [Homo sapiens] [Reaction:1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855169] I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol [Homo sapiens] previousReviewStatus [ReviewStatus:9821385] four stars releaseDate 2012-12-04 reviewed [InstanceEdit:9968059] Hill, David P, 2025-10-08 [InstanceEdit:9977084] Hill, David P, 2025-12-16 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:3200578] R-HSA-1855201.6 structureModified [InstanceEdit:9954157] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9968055] D'Eustachio, Peter, 2025-10-08 [InstanceEdit:9977080] D'Eustachio, Peter, 2025-12-16 summation [Summation:2023894] Inositol 1,3,4,6-tetrakisphosphate (I(1,3,4,6)P4) translocat... (hasEvent) [Pathway:1855196] IP3 and IP4 transport between cytosol and nucleus [Homo sapiens] (precedingEvent) [Reaction:1855228] I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus [Homo sapiens] (updatedInstance) [_UpdateTracker:9964680] Update Tracker - [Reaction:1855201] I(1,3,4,6)P4 transports from the cytosol to the nucleus - v94:[removeCatalystActivity] [_UpdateTracker:9971877] Update Tracker - [Reaction:1855201] I(1,3,4,6)P4 transports from the cytosol to the nucleus - v95:[addCatalystActivity, modifyText] [_UpdateTracker:9984664] Update Tracker - [Reaction:1855201] I(1,3,4,6)P4 transports from the cytosol to the nucleus - v96:[removeCatalystActivity]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by I(1,3,4,6)P4 transports from the cytosol to the nucleus (1855201)
