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Details on Person I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

Class:Id	Reaction:1855174
_displayName	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
_doRelease	TRUE
_timestamp	2025-09-22 08:49:30
authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2024033] inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5(4) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:9966600] RHEA:19798
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
input	[SimpleEntity:114520] I(1,4,5)P3 [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1889850] Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation [LiteratureReference:1675871] Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles [LiteratureReference:1675891] The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase [LiteratureReference:1889910] Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate
modified	[InstanceEdit:1884039] Williams, MG, 2011-10-31 [InstanceEdit:1889946] Williams, MG, 2011-11-01 [InstanceEdit:2024022] Williams, MG, 2011-12-13 [InstanceEdit:2562613] D'Eustachio, P, 2012-11-06 [InstanceEdit:2564838] D'Eustachio, P, 2012-11-07 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566471] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966597] Stephan, Ralf, 2025-09-22
name	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
output	[SimpleEntity:1629739] I(1,4)P2 [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane [Homo sapiens] [Reaction:1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol [Homo sapiens] [Reaction:1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol [Homo sapiens] [Reaction:1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol [Homo sapiens] [Reaction:1855200] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen [Homo sapiens] [Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens] [Reaction:167684] Active PLCG1 dissociates from TrkA receptor [Homo sapiens] [Reaction:212713] Active PLC-gamma1 dissociates from EGFR [Homo sapiens] [Reaction:2029272] Release of PLCG from FCGR [Homo sapiens] [Reaction:2029271] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:4420202] PLCG1 disassociates from VEGFR2 and translocate to PM [Homo sapiens] [Reaction:5654157] p-4Y-PLCG1 dissociates from activated FGFR2 [Homo sapiens] [Reaction:5654148] p-4Y-PLCG1 dissociates from activated FGFR3 [Homo sapiens] [Reaction:5654169] p-4Y-PLCG1 dissociates from activated FGFR4 [Homo sapiens] [Reaction:5654165] p-4Y-PLCG1 dissociates from activated FGFR1 [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200372] R-HSA-1855174.4
summation	[Summation:2024036] A group of inositol phosphatases dephosphorylate inositol 1,...
(hasEvent)	[Pathway:1855183] Synthesis of IP2, IP, and Ins in the cytosol [Homo sapiens]
(precedingEvent)	[Reaction:1855208] I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol [Homo sapiens]
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