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Details on Person I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol

Class:IdReaction:1855172
_displayNameI(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
_doReleaseTRUE
_timestamp2025-09-23 15:50:42
authored[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity[CatalystActivity:2023874] inositol-1,3,4-trisphosphate 5-kinase activity of ITPK1:Mg2+ [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference[DatabaseIdentifier:9966361] RHEA:13254
edited[InstanceEdit:1855226] Williams, MG, 2011-10-28
input[SimpleEntity:994123] I(1,3,4)P3 [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:994177] Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
modified[InstanceEdit:1884039] Williams, MG, 2011-10-31
[InstanceEdit:1889946] Williams, MG, 2011-11-01
[InstanceEdit:2023872] Williams, MG, 2011-12-13
[InstanceEdit:2240987] D'Eustachio, P, 2012-05-08
[InstanceEdit:2565867] D'Eustachio, P, 2012-11-08
[InstanceEdit:2566982] D'Eustachio, P, 2012-11-09
[InstanceEdit:2836586] D'Eustachio, P, 2012-12-11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9966360] Stephan, Ralf, 2025-09-21
[InstanceEdit:9966626] D'Eustachio, Peter, 2025-09-23
nameI(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
output[SimpleEntity:994170] I(1,3,4,5)P4 [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2012-12-04
reviewed[InstanceEdit:9966625] D'Eustachio, Peter, 2025-09-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200435] R-HSA-1855172.4
structureModified[InstanceEdit:9966360] Stephan, Ralf, 2025-09-21
summation[Summation:2023866] The broad-specificity enzyme inositol-tetrakisphosphate 1-ki...
(hasEvent)[Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol [Homo sapiens]
(precedingEvent)[Reaction:1855168] I(1,3,4,5)P4 transports from the cytosol to the nucleus [Homo sapiens]
[Reaction:1855186] I(1,3,4,5)P4 transports from the cytosol to the ER lumen [Homo sapiens]
[Reaction:1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol [Homo sapiens]
[Reaction:1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane [Homo sapiens]
[Reaction:1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971924] Update Tracker - [Reaction:1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol - v95:[removeOutput]
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