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Details on Person 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol

Class:Id	Reaction:1855158
_displayName	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
_doRelease	TRUE
_timestamp	2016-11-10 00:56:32
authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023988] inositol 5-diphosphate pentakisphosphate 5-kinase activity of IP6K1/3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
input	[SimpleEntity:1629765] 5-PP-IP5 [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1889803] Identification and characterization of a novel inositol hexakisphosphate kinase [LiteratureReference:1889876] Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups
modified	[InstanceEdit:1884039] Williams, MG, 2011-10-31 [InstanceEdit:1889946] Williams, MG, 2011-11-01 [InstanceEdit:2023998] Williams, MG, 2011-12-13 [InstanceEdit:2562613] D'Eustachio, P, 2012-11-06 [InstanceEdit:2564838] D'Eustachio, P, 2012-11-07 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
output	[SimpleEntity:1629759] 5-PPP-IP5 [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1855203] 5-PP-IP5 transports from the nucleus to the cytosol [Homo sapiens] [Reaction:1855207] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus [Homo sapiens] [Reaction:1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Homo sapiens] [Reaction:1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Homo sapiens] [Reaction:1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Homo sapiens] [Reaction:2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Homo sapiens] [Reaction:1855165] (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol [Homo sapiens] [Reaction:1855220] (PP)2-IP4 transports from the nucleus to the cytosol [Homo sapiens] [Reaction:1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol [Homo sapiens] [Reaction:1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200196] R-HSA-1855158.3
summation	[Summation:2024001] Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) pho...
(hasEvent)	[Pathway:1855167] Synthesis of pyrophosphates in the cytosol [Homo sapiens]
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