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Details on Person UniProt:Q9UN37 VPS4A
| Class:Id | ReferenceGeneProduct:184262 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-437 added on Sat February 7 2015;initiator methionine:1 removed on Tue November 3 2015;chain:2-437 removed on Tue November 3 2015;chain:1-437 added on Tue November 3 2015 |
| _displayName | UniProt:Q9UN37 VPS4A |
| _timestamp | 2025-02-21 19:24:14 |
| chain | chain:1-437 |
| checksum | C3CC556FB84F105C |
| comment | FUNCTION Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543).FUNCTION (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner (By similarity). Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST. Interacts with IST1. Interacts with ZFYVE19/ANCHR; leading to retain it at midbody.INTERACTION Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Flemming body.TISSUE SPECIFICITY Ubiquitously expressed.DOMAIN The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2).DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AAA ATPase family. |
| created | [InstanceEdit:184440] D'Eustachio, P, 2006-07-27 16:05:42 |
| description | recommendedName: fullName evidence="28"Vacuolar protein sorting-associated protein 4A ecNumber evidence="2"3.6.4.6 alternativeName: Protein SKD2 alternativeName: VPS4-1 shortName: hVPS4 |
| geneName | VPS4A VPS4 |
| identifier | Q9UN37 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cataract Cell cycle Cell division Congenital dyserythropoietic anemia Cytoplasm Cytoskeleton Disease variant Endosome Hereditary hemolytic anemia Hydrolase Intellectual disability Membrane Nucleotide-binding Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | VPS4A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992822] ENSEMBL:ENSG00000132612 VPS4A [Homo sapiens] |
| secondaryIdentifier | VPS4A_HUMAN B2RCB7 Q8TF07 Q9UI03 Q9Y582 |
| sequenceLength | 437 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:917732] VPS4A [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UN37 VPS4A (184262)
