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Details on Person Activated FGFR1 mutants and fusions bind PLCG1

Class:IdReaction:1839094
_displayNameActivated FGFR1 mutants and fusions bind PLCG1
_doReleaseTRUE
_timestamp2018-11-29 20:19:46
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:1839093] Rothfels, K, 2011-10-27
disease[Disease:1500689] cancer
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5654508] gain_of_function of Activated FGFR1 mutants and fusions [plasma membrane]
input[DefinedSet:5691527] Activated FGFR1 mutants and fusions [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:167682] PLCG1 [plasma membrane] [Homo sapiens]
[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
isChimericFALSE
literatureReference[LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
[LiteratureReference:2077411] FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies
[LiteratureReference:2029811] Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis
[LiteratureReference:2060759] Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner
[LiteratureReference:2033242] Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma
[LiteratureReference:191028] Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
[LiteratureReference:190978] Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F
[LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
[LiteratureReference:1637873] Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
[LiteratureReference:1679950] Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome
[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
modified[InstanceEdit:2105619] Rothfels, K, 2012-02-10
[InstanceEdit:2123550] Rothfels, K, 2012-02-14
[InstanceEdit:2156388] Rothfels, K, 2012-02-28
[InstanceEdit:2248846] Rothfels, K, 2012-05-15
[InstanceEdit:2275109] Rothfels, K, 2012-05-25
[InstanceEdit:5654507] Rothfels, Karen, 2014-12-03
[InstanceEdit:5655500] Rothfels, Karen, 2014-12-05
[InstanceEdit:5655614] Rothfels, Karen, 2014-12-05
[InstanceEdit:5691529] Rothfels, Karen, 2015-05-08
[InstanceEdit:5693997] Rothfels, Karen, 2015-05-19
[InstanceEdit:8853364] Rothfels, Karen, 2016-01-22
[InstanceEdit:9630190] Rothfels, Karen, 2018-11-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated FGFR1 mutants and fusions bind PLCG1
output[Complex:1839061] Activated FGFR1 mutants and fusions:PLCG1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2295175] R-HSA-1839094.4
summation[Summation:1839073] Although it has not been rigourously established, there is s...
(hasEvent)[Pathway:5655302] Signaling by FGFR1 in disease [Homo sapiens]
(precedingEvent)[Reaction:1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1 [Homo sapiens]
(replacementInstances)[_Deleted:8855781] Deletion of instance: 5655259
(updatedInstance)[_UpdateTracker:9784657] Update Tracker - [Reaction:1839094] Activated FGFR1 mutants and fusions bind PLCG1 - v53:[addLiteratureReference, add_removeInput, modifyText]
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