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Details on Person IFI16 binds cytosolic dsDNA

Class:IdReaction:1834951
_displayNameIFI16 binds cytosolic dsDNA
_doReleaseTRUE
_timestamp2017-07-26 05:30:47
authored[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
compartment[Compartment:70101] cytosol
created[InstanceEdit:1834959] Shamovsky, V, 2011-10-26
edited[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input[EntityWithAccessionedSequence:1834934] IFI16 [cytosol] [Homo sapiens]
[DefinedSet:9013802] IFI16 ligands [cytosol] [Human immunodeficiency virus 1]
isChimericFALSE
literatureReference[LiteratureReference:1834943] IFI16 is an innate immune sensor for intracellular DNA
[LiteratureReference:2453914] Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
[LiteratureReference:2453933] IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
modified[InstanceEdit:2408498] Shamovsky, V, 2012-07-17
[InstanceEdit:2422453] Shamovsky, V, 2012-07-19
[InstanceEdit:2422475] Shamovsky, V, 2012-07-19
[InstanceEdit:2429699] Shamovsky, V, 2012-08-09
[InstanceEdit:2453961] Shamovsky, V, 2012-08-18
[InstanceEdit:3134798] Shamovsky, V, 2013-02-13
[InstanceEdit:3597629] Shamovsky, V, 2013-05-21
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9013808] Shamovsky, Veronica, 2017-07-26
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIFI16 binds cytosolic dsDNA
output[Complex:1834947] dsDNA:IFI16 [cytosol] [Homo sapiens]
relatedSpecies[Species:5689680] Human herpesvirus 1
[Species:164493] Human immunodeficiency virus 1
[Species:8875362] Listeria monocytogenes
[Species:2671785] Vaccinia virus
releaseDate2012-09-18
reviewed[InstanceEdit:2422404] D'Eustachio, P, 2012-07-18
[InstanceEdit:2453959] Jin, Lei, 2012-08-18
[InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2465010] R-HSA-1834951.4
summation[Summation:1834955] Interferon (IFN)-inducible IFI16 protein was shown to be cri...
(hasEvent)[Pathway:1834941] STING mediated induction of host immune responses [Homo sapiens]
(precedingEvent)[Reaction:1834939] STING recruits TBK1 and IRF3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780666] Update Tracker - [Reaction:1834951] IFI16 binds cytosolic dsDNA - v62:[add_removeInput]
[_UpdateTracker:9787784] Update Tracker - [Reaction:1834951] IFI16 binds cytosolic dsDNA - v44:[add_removeInput]
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No pathways have been reviewed or authored by IFI16 binds cytosolic dsDNA (1834951)
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