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Details on Person CBL-CIN85-Endophilin complex mediates ligand-induced down-re...
| Class:Id | Summation:183099 |
|---|---|
| _displayName | CBL-CIN85-Endophilin complex mediates ligand-induced down-re... |
| _timestamp | 2016-08-10 20:08:51 |
| created | [InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47 |
| modified | [InstanceEdit:8934540] Orlic-Milacic, Marija, 2016-08-09 [InstanceEdit:8934559] Orlic-Milacic, Marija, 2016-08-10 |
| text | CBL-CIN85-Endophilin complex mediates ligand-induced down-regulation of the EGF receptor. The BAR domain of endophilin induces membrane curvature. The three SH3 domains of CIN85 bind to atypical proline-arginine motifs (PxxxPR) present in the carboxyl termini of CBL and CBL-b. In this way, CIN85 clusters CBL molecules, which is crucial for efficient EGFR endocytosis and degradation (Soubeyran et al. 2002). |
| (summation) | [Reaction:182994] Assembly of EGFR complex in clathrin-coated vesicles [Homo sapiens] [Reaction:9846403] GOCAM Assembly of EGFR complex in clathrin-coated vesicles [Homo sapiens] |
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No pathways have been reviewed or authored by CBL-CIN85-Endophilin complex mediates ligand-induced down-re... (183099)
