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Details on Person CBL binds and ubiquitinates phosphorylated Sprouty

Class:Id	Reaction:183089
_displayName	CBL binds and ubiquitinates phosphorylated Sprouty
_doRelease	TRUE
_timestamp	2011-09-07 19:13:24
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:183074] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
input	[Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] [Homo sapiens] [DefinedSet:182909] SPRY1/2 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:183004] hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl
modified	[InstanceEdit:188410] Jassal, B, 2006-10-12 13:36:05 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188574] Jassal, B, 2006-10-18 09:56:53 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:213442] Jassal, Bijay, 2008-02-26 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1525139] Orlic-Milacic, Marija, 2011-08-24 [InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CBL binds and ubiquitinates phosphorylated Sprouty
output	[Complex:182939] EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:182969] Phosphorylation of CBL (EGFR:CBL) [Homo sapiens] [Reaction:183055] Binding of CBL to EGFR [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358999] R-HSA-183089.2
summation	[Summation:188580] Sprouty is ubiquitinated by CBL in an EGF-dependent manner. ...
(hasEvent)	[Pathway:182971] EGFR downregulation [Homo sapiens]
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