Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person EGFR non-clathrin mediated endocytosis

Class:IdReaction:183072
_displayNameEGFR non-clathrin mediated endocytosis
_doReleaseTRUE
_timestamp2024-03-19 12:24:41
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
input[Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:182952] EPN1 [plasma membrane] [Homo sapiens]
[Complex:182947] EPS15:HGS:STAM [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:182937] EPS15L1 [plasma membrane] [Homo sapiens]
[Complex:8875480] CIN85:endophilin [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:183021] A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination
[LiteratureReference:183040] Clathrin-independent endocytosis of ubiquitinated cargos
modified[InstanceEdit:188417] Jassal, Bijay, 2006-10-12
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:213442] Jassal, Bijay, 2008-02-26
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8934540] Orlic-Milacic, Marija, 2016-08-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
nameEGFR non-clathrin mediated endocytosis
negativePrecedingEvent[NegativePrecedingEvent:9865821] Futile Cycle: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
output[Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361712] R-HSA-183072.4
summation[Summation:183068] At higher concentrations of ligand, a substantial fraction o...
(hasEvent)[Pathway:182971] EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:182986] CBL-mediated ubiquitination of CIN85 [Homo sapiens]
[Reaction:182990] Sprouty sequesters CBL away from active EGFR [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782820] Update Tracker - [Reaction:183072] EGFR non-clathrin mediated endocytosis - v58:[add_removeInput]
[_UpdateTracker:9789088] Update Tracker - [Reaction:183072] EGFR non-clathrin mediated endocytosis - v38:[modifyText]
[_UpdateTracker:9846660] Update Tracker - [Reaction:183072] EGFR non-clathrin mediated endocytosis - v84:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by EGFR non-clathrin mediated endocytosis (183072)
Follow Reactome