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Details on Person Localization of CBL:GRB2 to the membrane

Class:IdReaction:183067
_displayNameLocalization of CBL:GRB2 to the membrane
_doReleaseTRUE
_timestamp2024-03-19 12:24:51
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
edited[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
input[Complex:182910] CBL:GRB2 [cytosol] [Homo sapiens]
[Complex:182910] CBL:GRB2 [cytosol] [Homo sapiens]
[Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:183098] A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling
modified[InstanceEdit:186760] Jassal, B, 2006-08-15 09:18:02
[InstanceEdit:187069] Jassal, B, 2006-09-08 10:39:24
[InstanceEdit:188427] Jassal, B, 2006-10-12 13:57:04
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188569] Jassal, Bijay, 2006-10-18
[InstanceEdit:188582] Jassal, Bijay, 2006-10-18
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:213442] Jassal, Bijay, 2008-02-26
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1483058] Orlic-Milacic, Marija, 2011-08-12
[InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06
[InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07
[InstanceEdit:2018636] Jassal, Bijay, 2011-11-23
[InstanceEdit:9624469] Rothfels, Karen, 2018-10-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
nameLocalization of CBL:GRB2 to the membrane
negativePrecedingEvent[NegativePrecedingEvent:9865818] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
output[Complex:182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361380] R-HSA-183067.4
summation[Summation:183028] Upon EGF stimulation and consequent EGFR phosphorylation, GR...
(hasEvent)[Pathway:182971] EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:183058] Phosphorylation of CBL (EGFR:GRB2:CBL) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778915] Update Tracker - [Reaction:183067] Localization of CBL:GRB2 to the membrane - v67:[add_removeInput]
[_UpdateTracker:9789218] Update Tracker - [Reaction:183067] Localization of CBL:GRB2 to the membrane - v38:[add_removeInput]
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