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Details on Person Binding of CBL to EGFR

Class:Id	Reaction:183055
_displayName	Binding of CBL to EGFR
_doRelease	TRUE
_timestamp	2024-03-19 12:24:29
authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
input	[EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:183045] Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
modified	[InstanceEdit:187063] Jassal, B, 2006-09-08 09:48:46 [InstanceEdit:188423] Jassal, B, 2006-10-12 13:49:36 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188569] Jassal, Bijay, 2006-10-18 [InstanceEdit:188582] Jassal, Bijay, 2006-10-18 [InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:213442] Jassal, Bijay, 2008-02-26 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1482997] Orlic-Milacic, Marija, 2011-08-12 [InstanceEdit:1568624] Orlic-Milacic, Marija, 2011-09-06 [InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:6792595] Orlic-Milacic, Marija, 2015-08-25 [InstanceEdit:9031693] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9624436] Rothfels, Karen, 2018-10-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
name	Binding of CBL to EGFR
negativePrecedingEvent	[NegativePrecedingEvent:9865820] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
output	[Complex:182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177934] EGFR autophosphorylation [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:9851407] FAM83B, (FAM83A, FAM83D) bind EGFR [Homo sapiens] [Reaction:177937] Phosphorylation of EGFR by SRC kinase [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360689] R-HSA-183055.6
summation	[Summation:183088] Phosphorylation at tyrosine Y1069 (i.e. Y1045 in the mature ...
(hasEvent)	[Pathway:182971] EGFR downregulation [Homo sapiens]
(normalReaction)	[Reaction:1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [FailedReaction:5637794] EGFRvIII does not bind CBL [Homo sapiens]
(precedingEvent)	[Reaction:182969] Phosphorylation of CBL (EGFR:CBL) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778812] Update Tracker - [Reaction:183055] Binding of CBL to EGFR - v67:[add_removeInput] [_UpdateTracker:9779744] Update Tracker - [Reaction:183055] Binding of CBL to EGFR - v64:[add_removeInput] [_UpdateTracker:9789432] Update Tracker - [Reaction:183055] Binding of CBL to EGFR - v38:[add_removeInput, modifyText] [_UpdateTracker:9846674] Update Tracker - [Reaction:183055] Binding of CBL to EGFR - v84:[modifyText]
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No pathways have been reviewed or authored by Binding of CBL to EGFR (183055)