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Details on Person Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

Class:IdReaction:183002
_displayNameBeta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
_doReleaseTRUE
_timestamp2024-03-19 12:24:27
authored[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
edited[InstanceEdit:8951492] Jassal, Bijay, 2016-12-07
input[Complex:182917] Beta-Pix:CDC42:GTP [cytosol] [Homo sapiens]
[Complex:182917] Beta-Pix:CDC42:GTP [cytosol] [Homo sapiens]
[Complex:182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:182989] Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
modified[InstanceEdit:187062] Jassal, B, 2006-09-08 09:47:16
[InstanceEdit:188425] Jassal, B, 2006-10-12 13:55:20
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188569] Jassal, Bijay, 2006-10-18
[InstanceEdit:188582] Jassal, Bijay, 2006-10-18
[InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:212475] Jassal, Bijay, 2008-02-12
[InstanceEdit:213442] Jassal, Bijay, 2008-02-26
[InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1525138] Orlic-Milacic, Marija, 2011-08-24
[InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07
[InstanceEdit:8951492] Jassal, Bijay, 2016-12-07
[InstanceEdit:8951712] Jassal, Bijay, 2016-12-09
[InstanceEdit:8951713] Jassal, Bijay, 2016-12-09
[InstanceEdit:8979568] Jassal, Bijay, 2017-02-27
[InstanceEdit:9031696] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
nameBeta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
Beta-Pix pushes CIN85 away from CBL
output[Complex:8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360448] R-HSA-183002.5
summation[Summation:183092] High concentrations of active CDC42 (bound to GTP) and Beta-...
(hasEvent)[Pathway:182971] EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779698] Update Tracker - [Reaction:183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - v64:[add_removeInput]
[_UpdateTracker:9781635] Update Tracker - [Reaction:183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - v60:[add_removeOutput, modifyText]
[_UpdateTracker:9789455] Update Tracker - [Reaction:183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - v38:[modifyText]
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No pathways have been reviewed or authored by Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (183002)
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