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Details on Person Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA

Class:Id	Reaction:182876
_displayName	Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
_doRelease	TRUE
_timestamp	2015-07-14 14:59:57
authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
goBiologicalProcess	[GO_BiologicalProcess:17126] RNA-templated DNA biosynthetic process
input	[Complex:188560] RTC with duplex DNA containing discontinuous plus strand flap [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:182836] 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus [LiteratureReference:182816] Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro [LiteratureReference:182817] Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1
modified	[InstanceEdit:182890] Gopinathrao, G, 2006-07-20 19:02:21 [InstanceEdit:183136] D'Eustachio, P, 2006-07-21 15:54:07 [InstanceEdit:184166] Gopinathrao, G, 2006-07-25 04:37:17 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188568] Gopinathrao, G, 2006-10-17 20:24:07 [InstanceEdit:188941] Gopinathrao, G, 2006-10-30 22:24:14 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:2594924] Gillespie, ME, 2012-11-19 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:6787545] D'Eustachio, Peter, 2015-07-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
output	[Complex:175254] RTC with integration competent viral DNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:164505] Synthesis of full-length duplex viral DNA with a discontinuous plus strand [Homo sapiens] [Reaction:164512] Second strand transfer by annealing complementary PBS sequences [Homo sapiens]
regulatedBy	[Requirement:182796] Requirement by 'LIG1 [nucleoplasm]' [Requirement:182825] Requirement by 'FEN1 [nucleoplasm]'
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358843] R-HSA-182876.4
summation	[Summation:182811] The fate of the discontinuous viral DNA duplex synthesized i...
(hasEvent)	[Pathway:162594] Early Phase of HIV Life Cycle [Homo sapiens]
(precedingEvent)	[Reaction:8951690] Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784474] Update Tracker - [Reaction:182876] Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA - v54:[addLiteratureReference]
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