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Details on Person As the reverse transcriptase activity of the HIV-1 RT hetero...
| Class:Id | Summation:182827 |
|---|---|
| _displayName | As the reverse transcriptase activity of the HIV-1 RT hetero... |
| _timestamp | 2006-10-17 19:40:09 |
| created | [InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19 |
| literatureReference | [LiteratureReference:177451] Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities. [LiteratureReference:177439] Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer [LiteratureReference:182870] Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities [LiteratureReference:182867] Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids [LiteratureReference:182833] Mechanism and fidelity of HIV reverse transcriptase [LiteratureReference:188334] Two defective forms of reverse transcriptase can complement to restore retroviral infectivity |
| modified | [InstanceEdit:188333] Gopinathrao, G, 2006-10-06 22:15:12 [InstanceEdit:188558] D'Eustachio, P, 2006-10-17 19:40:04 |
| text | As the reverse transcriptase activity of the HIV-1 RT heterodimer catalyzes the extension of the minus-strand DNA, the RNaseH activity catalyzes the degradation of the complementary viral genomic RNA sequences. Telesnitsky and Goff (1993) observed that two defective forms of reverse transcriptase can complement to restore retroviral infectivity. The RNase H active site is positioned within the HIV-1 RT heterodimer so as to attack the RNA strand of the RNA:DNA duplex at a point 18 bases behind the site of reverse transcription (Furfine and Reardon 1991; Ghosh et al. 1995; Gopalakrishnan et al. 1992; Wohrl and Moelling 1990). The rate of RNase H cleavage is substantially lower than the rate of DNA synthesis and the level of its activity in vivo is unclear, however (Kati et al. 1992). The product of these combined DNA synthesis and RNA degradation events is a DNA strand still duplexed with extended viral genomic RNA fragments. |
| (summation) | [Reaction:164528] RNase H-mediated cleavage of the template strand [Homo sapiens] |
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