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Details on Person The rate of RNase H cleavage is substantially lower than the...
| Class:Id | Summation:182818 |
|---|---|
| _displayName | The rate of RNase H cleavage is substantially lower than the... |
| _timestamp | 2006-10-17 19:40:11 |
| created | [InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19 |
| literatureReference | [LiteratureReference:182833] Mechanism and fidelity of HIV reverse transcriptase [LiteratureReference:182868] The sequential mechanism of HIV reverse transcriptase RNase H [LiteratureReference:182873] Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H |
| modified | [InstanceEdit:188333] Gopinathrao, G, 2006-10-06 22:15:12 [InstanceEdit:188558] D'Eustachio, P, 2006-10-17 19:40:04 |
| text | The rate of RNase H cleavage is substantially lower than the rate of DNA synthesis (Kati et al. 1992), so the product of the combined DNA synthesis and RNA degradation events catalyzed by the RT heterodimer mediating minus-strand strong stop DNA (-sssDNA) synthesis is a DNA segment still duplexed with extended viral genomic RNA fragments. In vitro, other RT heterodimers bind the remaining RNA:DNA heteroduplexes and their RNase H domains further degrade the viral genomic RNA (Wisniewski et al. 2000a, b). |
| (summation) | [Reaction:182859] RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex [Homo sapiens] |
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No pathways have been reviewed or authored by The rate of RNase H cleavage is substantially lower than the... (182818)
