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Details on Person The fate of the discontinuous viral DNA duplex synthesized i...
| Class:Id | Summation:182811 |
|---|---|
| _displayName | The fate of the discontinuous viral DNA duplex synthesized i... |
| _timestamp | 2006-10-06 22:15:36 |
| created | [InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19 |
| literatureReference | [LiteratureReference:182836] 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus [LiteratureReference:182816] Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro [LiteratureReference:182817] Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1 |
| modified | [InstanceEdit:183136] D'Eustachio, P, 2006-07-21 15:54:07 [InstanceEdit:188333] Gopinathrao, G, 2006-10-06 22:15:12 |
| text | The fate of the discontinuous viral DNA duplex synthesized in the cytosol of an infected cell by HIV-1 reverse transcriptase is not entirely clear. Studies of some viral systems suggest that this discontinuous structure is required for passage of the viral duplex DNA into the nucleus while there are evidence contrary to this observation. Studies in vitro indicate that human nuclear flap endonuclease and DNA ligase can remove the flap and seal the plus-strand discontinuity in HIV-1 DNA (Miller et al. 1995; Rausch and Le Grice 2004; Rumbaugh et al. 1998), although role of flap is not yet clear. |
| (summation) | [Reaction:182876] Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA [Homo sapiens] |
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