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Details on Person RNase H-mediated degradation of the template strand

Class:Id	Reaction:182795
_displayName	RNase H-mediated degradation of the template strand
_doRelease	TRUE
_timestamp	2014-08-29 21:16:37
authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:182888] RNA-DNA hybrid ribonuclease activity of RTC with extensive RNase-H digestion [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
figure	[Figure:180422] /figures/RT_event4.jpg
input	[Complex:173789] RTC with extensive RNase-H digestion [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:182866] A second origin of DNA plus-strand synthesis is required for optimal Human Immunodeficiency Virus replication [LiteratureReference:177421] Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage [LiteratureReference:177435] The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase [LiteratureReference:182868] The sequential mechanism of HIV reverse transcriptase RNase H [LiteratureReference:182873] Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
modified	[InstanceEdit:182890] Gopinathrao, G, 2006-07-20 19:02:21 [InstanceEdit:184166] Gopinathrao, G, 2006-07-25 04:37:17 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188941] Gopinathrao, G, 2006-10-30 22:24:14 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNase H-mediated degradation of the template strand
output	[Complex:173764] RTC with extending minus strand DNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:164528] RNase H-mediated cleavage of the template strand [Homo sapiens] [Reaction:164520] Minus strand DNA synthesis resumes [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359635] R-HSA-182795.2
summation	[Summation:177427] The rate of RNase H cleavage is substantially lower than the...
(hasEvent)	[Pathway:164516] Minus-strand DNA synthesis [Homo sapiens]
(precedingEvent)	[Reaction:164513] 3' PPT-primed initiation of plus-strand DNA synthesis [Homo sapiens]
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No pathways have been reviewed or authored by RNase H-mediated degradation of the template strand (182795)