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Details on Person In addition to telomerase-mediated elongation and C-strand s...
| Class:Id | Summation:182743 |
|---|---|
| _displayName | In addition to telomerase-mediated elongation and C-strand s... |
| _timestamp | 2019-12-11 21:18:46 |
| created | [InstanceEdit:182722] Gillespie, ME, 2006-07-12 20:12:47 |
| literatureReference | [LiteratureReference:182734] Human telomeres have different overhang sizes at leading versus lagging strands [LiteratureReference:182744] Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres [LiteratureReference:182714] Closed chromatin loops at the ends of chromosomes [LiteratureReference:182740] Condensation of rat telomere-specific nucleosomal arrays containing unusually short DNA repeats and histone H1 [LiteratureReference:177177] Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres [LiteratureReference:182741] Cell cycle-dependent regulation of yeast telomerase by Ku [LiteratureReference:177185] Cell cycle-regulated trafficking of human telomerase to telomeres [LiteratureReference:182735] Est1p as a cell cycle-regulated activator of telomere-bound telomerase [LiteratureReference:182721] Functional human telomeres are recognized as DNA damage in G2 of the cell cycle [LiteratureReference:182713] Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae [LiteratureReference:182738] Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo |
| modified | [InstanceEdit:9670647] Orlic-Milacic, Marija, 2019-12-11 |
| text | In addition to telomerase-mediated elongation and C-strand synthesis, other DNA processing steps are likely involved in telomere maintenance. In humans, nucleolytic activity is proposed to be involved in generating the G-rich 3' single strand overhang. In addition, differences in the structure of the overhang at telomeres that have undergone leading vs. lagging strand replication suggest that DNA processing may be different at these telomeres (Chai et al. 2006). Many proteins associate with telomeric DNA. One complex that binds telomeres is called shelterin. Shelterin is a six-protein complex composed of TRF1 and TRF2, which can bind double-stranded telomeric DNA, POT1, which can bind single-stranded telomeric DNA, and three other factors, RAP1, TIN2, and TPP1 (reviewed in de Lange 2006 "Telomeres"). Human telomeric DNA is also bound by nucleosomes (Makarov et al. 1993; Nikitina and Woodcock 2004). A number of other proteins, including some that play roles in the DNA damage response, can be found at telomeres (Zhu et al. 2000; Verdun et al. 2005). Studies in yeast and humans indicate that the association of many proteins with telomeres is regulated through the cell cycle (Zhu et al. 2000; Taggart et al. 2002; Fisher et al. 2004; Takata et al. 2004; Takata et al. 2005; Verdun et al. 2005). For instance, TRF1, MRE11, POT1, ATM, and NBS1 display cell cycle regulated chromatin immunoprecipitation of telomeric DNA (Zhu et al. 2000; Verdun et al. 2005), and cytologically observable hTERT and hTERC localize to a subset of telomeres only in S-phase (Jady et al. 2006; Tomlinson et al. 2006). These data indicate that telomeres are dynamically remodeled through the cell cycle. |
| (summation) | [Reaction:181450] Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure [Homo sapiens] |
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