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Details on Person Association of INK4 family proteins with CDK4/6

Class:Id	Reaction:182594
_displayName	Association of INK4 family proteins with CDK4/6
_doRelease	TRUE
_timestamp	2019-05-07 21:28:02
authored	[InstanceEdit:182593] Matthews, L, 2006-07-10 19:18:57
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:182593] Matthews, L, 2006-07-10 19:18:57
edited	[InstanceEdit:167002] Matthews, L, 2005-10-07 06:13:50 [InstanceEdit:8941988] Orlic-Milacic, Marija, 2016-10-07
goBiologicalProcess	[GO_BiologicalProcess:1043034] negative regulation of G1/S transition of mitotic cell cycle
input	[DefinedSet:182588] INK4 [cytosol] [Homo sapiens] [DefinedSet:69209] CDK4,CDK6 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:182601] A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 [LiteratureReference:182566] p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest [LiteratureReference:182595] Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function [LiteratureReference:182600] Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4 [LiteratureReference:8941982] Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
modified	[InstanceEdit:182624] Matthews, L, 2006-07-11 10:43:36 [InstanceEdit:182781] Matthews, L, 2006-07-13 11:57:47 [InstanceEdit:3779452] Orlic-Milacic, M, 2013-06-27 [InstanceEdit:3877064] Orlic-Milacic, M, 2013-07-10 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:8932657] Orlic-Milacic, Marija, 2016-07-27 [InstanceEdit:8941986] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8941987] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8942683] Orlic-Milacic, Marija, 2016-10-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8949904] Orlic-Milacic, Marija, 2016-11-30 [InstanceEdit:8949928] Orlic-Milacic, Marija, 2016-12-01 [InstanceEdit:9021302] Orlic-Milacic, Marija, 2017-09-15 [InstanceEdit:9628165] D'Eustachio, Peter, 2018-11-06 [InstanceEdit:9645268] Orlic-Milacic, Marija, 2019-05-07 [InstanceEdit:9645279] Orlic-Milacic, Marija, 2019-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of INK4 family proteins with CDK4/6
output	[Complex:182579] CDK4,CDK6:INK4 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:3209114] Translation of p16INK4A mRNA is inhibited by miR-24 [Homo sapiens] [Reaction:3209151] miR-24 binds p16INK4A and p14ARF mRNAs [Homo sapiens] [BlackBoxEvent:3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription [Homo sapiens] [BlackBoxEvent:8853921] VENTX stimulates p16-INK4A transcription [Homo sapiens] [BlackBoxEvent:3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA [Homo sapiens] [BlackBoxEvent:3857348] Activated CEBPB stimulates transcription of CDKN2B [Homo sapiens] [Reaction:3857345] Activated CEBPB binds CDKN2B promoter [Homo sapiens] [BlackBoxEvent:2187303] SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B [Homo sapiens] [Reaction:9736979] p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter [Homo sapiens]
releaseDate	2006-08-02
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:8949903] Roger, Pierre P, 2016-11-04 [InstanceEdit:9645278] Bennett, Dorothy C, 2019-04-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361669] R-HSA-182594.8
summation	[Summation:182625] Prior to mitogen activation, the inhibitory proteins of the ...
(hasEvent)	[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens] [Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens] [Pathway:2559582] Senescence-Associated Secretory Phenotype (SASP) [Homo sapiens] [Pathway:2559585] Oncogene Induced Senescence [Homo sapiens]
(normalReaction)	[FailedReaction:9630792] p16INK4A mutants do not bind CDK4 [Homo sapiens] [FailedReaction:9630795] p16INK4A mutants do not bind CDK4,CDK6 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777817] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v69:[modifyText] [_UpdateTracker:9781607] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v60:[modifyText] [_UpdateTracker:9782433] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v59:[addLiteratureReference, modifyText] [_UpdateTracker:9787429] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v45:[modifyText]
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