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Details on Person Lax, I

Class:Id	Person:182118
_displayName	Lax, I
_timestamp	2011-05-09 19:16:57
created	[InstanceEdit:182123] Jassal, B, 2006-07-06 08:19:58
firstname	Irit
initial	I
modified	[InstanceEdit:1268134] Rothfels, K, 2011-05-09
surname	Lax
(author)	[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors [LiteratureReference:188658] The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway [LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:189933] All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors [LiteratureReference:191015] Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:208203] Two EGF molecules contribute additively to stabilization of the EGFR dimer [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation [LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl List all 17 refering instances
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No pathways have been reviewed or authored by Lax, I (182118)