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Details on Person botC LC cleaves target cell STX1

Class:IdReaction:181567
_displayNamebotC LC cleaves target cell STX1
_doReleaseTRUE
_timestamp2020-10-08 22:00:42
authored[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity[CatalystActivity:168781] metalloendopeptidase activity of botC LC:Zn2+ [cytosol]
catalystActivityReference[CatalystActivityReference:9643247] metalloendopeptidase activity of BoNT/C LC:Zn2+ [cytosol] Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:181561] Gopinathrao, G, 2006-06-14 16:40:11
disease[Disease:3632909] botulism
edited[InstanceEdit:181692] Gopinathrao, G, 2006-06-15 22:12:29
input[DefinedSet:5250514] STX1 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:5246522] Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin
[LiteratureReference:181711] Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release
[LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins
[LiteratureReference:379281] The synaptic vesicle cycle
modified[InstanceEdit:181694] Gopinathrao, G, 2006-06-15 22:14:17
[InstanceEdit:181756] Gopinathrao, G, 2006-06-16 17:36:48
[InstanceEdit:190033] Gopinathrao, G, 2006-12-13 17:03:37
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:194803] Gopinathrao, G, 2007-03-27 17:24:22
[InstanceEdit:194837] Gopinathrao, G, 2007-03-29 10:41:15
[InstanceEdit:197013] Gopinathrao, G, 2007-04-30 09:21:41
[InstanceEdit:200989] Gopinathrao, G, 2007-07-27 15:43:30
[InstanceEdit:201181] Gopinathrao, G, 2007-08-01 20:04:38
[InstanceEdit:201290] Gopinathrao, G, 2007-08-03 17:41:26
[InstanceEdit:201316] Gopinathrao, G, 2007-08-03 18:19:30
[InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29
[InstanceEdit:2648976] D'Eustachio, P, 2012-11-21
[InstanceEdit:3632911] Gillespie, ME, 2013-05-28
[InstanceEdit:5228354] D'Eustachio, Peter, 2014-01-10
[InstanceEdit:5250512] D'Eustachio, Peter, 2014-01-25
[InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11
[InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23
[InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namebotC LC cleaves target cell STX1
output[DefinedSet:5250515] STX1(1-?) [cytosol] [Homo sapiens]
[DefinedSet:5250513] STX1(?-288) [plasma membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:168825] Clostridium botulinum
releaseDate2007-08-21
reviewed[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25
[InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358507] R-HSA-181567.4
summation[Summation:181687] Botulinum toxin type C light chain (botC LC), in the cytosol...
(hasEvent)[Pathway:5250971] Toxicity of botulinum toxin type C (botC) [Homo sapiens]
(replacementInstances)[_Deleted:5251002] Deletion of instance: 181546
[_Deleted:5251013] Deletion of instance: 168782
(updatedInstance)[_UpdateTracker:9776522] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v75:[modifyText]
[_UpdateTracker:9786326] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v50:[modifyText]
[_UpdateTracker:9786729] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v48:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by botC LC cleaves target cell STX1 (181567)
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