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Details on Person TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationa...
| Class:Id | Summation:181444 |
|---|---|
| _displayName | TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationa... |
| _timestamp | 2011-07-14 15:32:35 |
| created | [InstanceEdit:181443] de Bono, B, 2006-06-13 10:53:46 |
| modified | [InstanceEdit:181447] de Bono, B, 2006-06-13 11:07:52 [InstanceEdit:181935] de Bono, B, 2006-07-03 09:52:28 [InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13 [InstanceEdit:1449548] D'Eustachio, P, 2011-07-14 |
| text | TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003). |
| (summation) | [Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade [Homo sapiens] |
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No pathways have been reviewed or authored by TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationa... (181444)
