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Details on Person SRC family kinases phosphorylate ERBB2 (in complex with ERBB3)

Class:IdReaction:1810442
_displayNameSRC family kinases phosphorylate ERBB2 (in complex with ERBB3)
_timestamp2016-07-15 23:50:33
catalystActivity[CatalystActivity:1810443] protein tyrosine kinase activity of p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643483] protein tyrosine kinase activity of p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:1810439] Orlic-Milacic, M, 2011-10-24
input[Complex:1247502] NRG1/2:ERBB3:ERBB2 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1810436] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9643047] Wu, G, 2019-04-04
nameSRC family kinases phosphorylate ERBB2 (in complex with ERBB3)
output[Complex:1810433] NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8922985] R-HSA-1810442.1
summation[Summation:1810427] Dissociation of HSP90 from ERBB2 upon formation of ERBB2 het...
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No pathways have been reviewed or authored by SRC family kinases phosphorylate ERBB2 (in complex with ERBB3) (1810442)
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