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Details on Person The HIV-1 Vif protein associates with the DNA editing enzyme...

Class:IdSummation:180734
_displayNameThe HIV-1 Vif protein associates with the DNA editing enzyme...
_timestamp2007-01-30 14:00:02
created[InstanceEdit:180726] Matthews, L, 2006-06-02 09:30:33
literatureReference[LiteratureReference:180674] HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation
[LiteratureReference:192231] Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F
[LiteratureReference:192271] A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif)
[LiteratureReference:192272] A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor
modified[InstanceEdit:192273] Matthews, L, 2007-01-30 13:59:53
textThe HIV-1 Vif protein associates with the DNA editing enzyme APOBEC3G Marin et al) . The binding site has not yet been mapped but emerging evidence suggest that the N-terminal lregion of Vif is essential for APOBEC3G recognition (Tian et al) .
Substitution of a single amino acid in the human APOBEC3G (Asp128Lys) abolishes binding and renders it resistant to HIV-1 Vif (Schrofelbauer et al; Bogerd et al.).
(summation)[Reaction:180602] Association of Vif with APOBEC3G [Homo sapiens]
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