Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person During reverse transcription, APOBEC3G-mediated minus-strand...

Class:IdSummation:180706
_displayNameDuring reverse transcription, APOBEC3G-mediated minus-strand...
_timestamp2013-11-26 19:29:04
created[InstanceEdit:180726] Matthews, L, 2006-06-02 09:30:33
literatureReference[LiteratureReference:180669] Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
[LiteratureReference:192255] Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B
[LiteratureReference:180678] The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
modified[InstanceEdit:182368] Matthews, L, 2006-07-07 14:32:15
[InstanceEdit:182886] D'Eustachio, P, 2006-07-20 16:22:44
[InstanceEdit:192264] Matthews, L, 2007-01-30 13:58:36
[InstanceEdit:192286] Matthews, L, 2007-01-30 22:50:13
[InstanceEdit:5173312] D'Eustachio, P, 2013-11-26
textDuring reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004).
The polypurine tract is essential for plus strand synthesis and is located at the 3' end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5' to 3' regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)
(summation)[Reaction:180632] Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by During reverse transcription, APOBEC3G-mediated minus-strand... (180706)
Follow Reactome