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Details on Person PIK3CA:PIK3R1 [cytosol]
Class:Id Complex:1806218 _displayName PIK3CA:PIK3R1 [cytosol] _timestamp 2012-05-31 10:14:52 compartment [Compartment:70101] cytosol created [InstanceEdit:1806251] Williams, MG, 2011-10-24 hasComponent
isChimeric FALSE name PIK3CA:PIK3R1 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2296707] R-HSA-1806218.1 (activeUnit) [CatalystActivity:8852032] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] [CatalystActivity:9028757] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] [CatalystActivity:9603444] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] [CatalystActivity:9664662] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3:PI3K [plasma membrane] [CatalystActivity:9664939] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane] (hasComponent) [Complex:179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:1226013] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:1250373] PI3K:p-ERBB4cyt1 [plasma membrane] [Homo sapiens] [Complex:1306974] NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] [Homo sapiens] [Complex:5637693] p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:8851953] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:9028508] BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] [Homo sapiens] [Complex:9603404] NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] [Homo sapiens] [Complex:9654210] Phosphorylated ERBB2 L755S,(ERBB2 L755M,ERBB2 L755W):ERBB3 heterodimer:PI3K [plasma membrane] [Homo sapiens] [Complex:9654244] Phosphorylated EGF:EGFR:ERBB2 L755S,(ERBB2 L755M,ERBB2 L755W) heterodimer:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] (hasMember) [DefinedSet:1806189] PIK3(2) [cytosol] [Homo sapiens] [DefinedSet:1806233] PIK3C(1) [cytosol] [Homo sapiens] [DefinedSet:9012640] PI3K alpha, gamma [cytosol] [Homo sapiens] [DefinedSet:9680346] PIK3CA,B,D:PIK3R1 [cytosol] [Homo sapiens] (input) [Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens] [Reaction:1226012] Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Homo sapiens] [Reaction:1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Homo sapiens] [Reaction:1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers [Homo sapiens] [Reaction:1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Homo sapiens] [Reaction:5637765] Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII [Homo sapiens] [Reaction:8851954] Phosphorylated GAB1 recruits PI3K to MET [Homo sapiens] [BlackBoxEvent:9028505] Activated NTRK2 recruits PI3K [Homo sapiens] [Reaction:9603407] Activated NTRK3 binds PI3K [Homo sapiens]
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