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Details on Person Degradation of ubiquitinated CD4

Class:Id	BlackBoxEvent:180573
_displayName	Degradation of ubiquitinated CD4
_doRelease	TRUE
_timestamp	2014-12-12 21:44:04
authored	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:180586] Matthews, L, 2006-05-23 13:59:44
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
edited	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
input	[Complex:180530] multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] [Homo sapiens]
literatureReference	[LiteratureReference:180533] A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
modified	[InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19 [InstanceEdit:188231] Matthews, L, 2006-10-03 22:02:57 [InstanceEdit:188244] Matthews, L, 2006-10-04 21:43:33 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:5656435] Gillespie, Marc E, 2014-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Degradation of ubiquitinated CD4
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [Complex:180567] Vpu:beta-TrCP1:Skp1 complex [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex [Homo sapiens] [Reaction:180599] The Vpu:CD4:beta-TrCP complex recruits SKP1 [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewed	[InstanceEdit:188242] Benarous, R, 2006-09-21 14:25:23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361936] R-HSA-180573.2
summation	[Summation:188232] Ubiquitinated CD4 is then subject to proteasome-mediated deg...
(hasEvent)	[Pathway:180534] Vpu mediated degradation of CD4 [Homo sapiens]
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