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Details on Person EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]

Class:IdComplex:180286
_displayNameEGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
_timestamp2018-10-11 15:14:02
compartment[Compartment:876] plasma membrane
created[InstanceEdit:180315] Jassal, B, 2006-05-18 13:16:38
hasComponent
modified[InstanceEdit:1483240] Orlic-Milacic, Marija, 2011-08-12
[InstanceEdit:2018636] Jassal, Bijay, 2011-11-23
[InstanceEdit:2231000] Matthews, L, 2012-05-07
[InstanceEdit:9038402] Orlic-Milacic, Marija, 2018-02-26
[InstanceEdit:9624448] Rothfels, Karen, 2018-10-11
nameEGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1
GRB2:Phospho GAB1-EGF-Phospho-EGFR dimer
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:371959] R-HSA-180286.3
(hasComponent)[Complex:179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [Homo sapiens]
[Complex:180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Homo sapiens]
(input)[Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens]
[Reaction:177944] Activation of SHP2 through the binding to phospho-Gab1 [Homo sapiens]
[Reaction:9846369] GOCAM Activation of SHP2 through the binding to phospho-Gab1 [Homo sapiens]
[Reaction:9846385] GOCAM PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:5637725] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane]
[EntityFunctionalStatus:9630101] gain_of_function of p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane]
(output)[Reaction:177930] GAB1 phosphorylation by EGFR kinase [Homo sapiens]
[Reaction:9846400] GOCAM GAB1 phosphorylation by EGFR kinase [Homo sapiens]
(physicalEntity)[CatalystActivity:9851192] signaling adaptor activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
[CatalystActivity:9851195] signaling adaptor activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
(updatedInstance)[_UpdateTracker:9870698] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v38:[addName, updateContainedComponent]
[_UpdateTracker:9871239] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v39:[updateContainedComponent]
[_UpdateTracker:9871653] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v40:[addCompartment]
[_UpdateTracker:9872521] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent]
[_UpdateTracker:9894466] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v57:[updateContainedComponent]
[_UpdateTracker:9898622] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v64:[add_removeHasComponent]
[_UpdateTracker:9899704] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v67:[add_removeHasComponent, modifyName, updateContainedComponent]
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No pathways have been reviewed or authored by EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (180286)
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