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Details on Person Expression of Carnitine O-palmitoyltransferase 1 CPT1A

Class:Id	BlackBoxEvent:1801587
_displayName	Expression of Carnitine O-palmitoyltransferase 1 CPT1A
_doRelease	TRUE
_timestamp	2025-07-21 16:37:42
authored	[InstanceEdit:1799319] May, B, 2011-10-23
compartment	[Compartment:7660] nucleoplasm [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:1801584] May, B, 2011-10-23
edited	[InstanceEdit:1799319] May, B, 2011-10-23
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
inferredFrom	[BlackBoxEvent:1368145] Expression of Cpt1a [Mus musculus]
input	[EntityWithAccessionedSequence:5641230] CPT1A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1801582] Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene [LiteratureReference:561153] Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human [LiteratureReference:400114] Regulation of P450 4A expression by peroxisome proliferator activated receptors
modified	[InstanceEdit:1801592] May, B, 2011-10-24 [InstanceEdit:1989744] May, B, 2011-11-13 [InstanceEdit:2084234] May, B, 2012-01-30 [InstanceEdit:5641233] May, Bruce, 2014-11-16 [InstanceEdit:5663276] May, Bruce, 2015-01-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626989] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9697139] May, Bruce, 2020-08-06 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9934287] May, Bruce, 2025-01-07 [InstanceEdit:9936575] May, Bruce, 2025-01-23 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08 [InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21
name	Expression of Carnitine O-palmitoyltransferase 1 CPT1A
output	[EntityWithAccessionedSequence:400161] CPT1A [mitochondrial outer membrane] [Homo sapiens]
precedingEvent	[Reaction:5663264] RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene [Homo sapiens] [BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens] [BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens] [Reaction:2026996] FABP1 transports fatty acids into the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:1801583] Positive gene expression regulation by 'RORA:EP300:CPT1A gene [nucleoplasm]' [PositiveGeneExpressionRegulation:1989798] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]'
regulationReference	[RegulationReference:9641397] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human [RegulationReference:9642555] Positive gene expression regulation by 'RORA:EP300:CPT1A gene [nucleoplasm]' RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR
releaseDate	2011-12-06
reviewed	[InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:2084235] Delaunay, F, 2012-01-28 [InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016210] R-HSA-1801587.9
summation	[Summation:1801585] The CPT1A gene is transcribed to yield mRNA and the mRNA is ...
(hasEvent)	[Pathway:1989781] PPARA activates gene expression [Homo sapiens] [Pathway:9933387] RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775706] Update Tracker - [BlackBoxEvent:1801587] Expression of CPT1A - v78:[addSummation] [_UpdateTracker:9784951] Update Tracker - [BlackBoxEvent:1801587] Expression of CPT1A - v52:[add_removeRegulator] [_UpdateTracker:9785624] Update Tracker - [BlackBoxEvent:1801587] Expression of CPT1A - v51:[addInput] [_UpdateTracker:9939683] Update Tracker - [BlackBoxEvent:1801587] Expression of Carnitine O-palmitoyltransferase 1 CPT1A - v92:[addSummation, modifyText]
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