Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The formation of 2-LTR circles requires the action of the ce...
| Class:Id | Summation:180109 |
|---|---|
| _displayName | The formation of 2-LTR circles requires the action of the ce... |
| _timestamp | 2006-05-18 20:00:08 |
| created | [InstanceEdit:180083] Gopinathrao, G, 2006-05-16 19:02:00 |
| literatureReference | [Book:175927] 9780879695712 Integration Retroviruses Coffin, JM [LiteratureReference:180115] Roles of host cell factors in circularization of retroviral dna |
| modified | [InstanceEdit:180396] Gopinathrao, G, 2006-05-18 19:59:47 |
| text | The formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this is provided by the observation that cells mutant in these functions do not support detectable formation of 2-LTR circles, though integration and formation of 1-LTR circles are mostly normal. The reaction takes place in the nucleus, and formation of 2-LTR circles has been used as a surrogate assay for nuclear transport. It has also been suggested that the NHEJ system affects the toxicity of retroviral infection. |
| (summation) | [Pathway:164843] 2-LTR circle formation [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The formation of 2-LTR circles requires the action of the ce... (180109)
