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Details on Person A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
| Class:Id | LiteratureReference:179899 |
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| _displayName | A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling |
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| _timestamp | 2006-05-09 12:53:53 |
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| author | [Person:179823] Rodrigues, GA
[Person:179900] Falasca, M
[Person:179877] Zhang, Z
[Person:179829] Ong, SH
[Person:179800] Schlessinger, J |
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| created | [InstanceEdit:179808] Jassal, Bijay, 2006-05-09 |
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| journal | Mol Cell Biol |
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| pages | 1448-59 |
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| pubMedIdentifier | 10648629 |
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| title | A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling |
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| volume | 20 |
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| year | 2000 |
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| (literatureReference) | [Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens]
[Reaction:177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Homo sapiens]
[Reaction:179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens]
[Reaction:5637765] Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII [Homo sapiens]
[Pathway:6806834] Signaling by MET [Homo sapiens]
[Pathway:8851907] MET activates PI3K/AKT signaling [Homo sapiens]
[Reaction:8851954] Phosphorylated GAB1 recruits PI3K to MET [Homo sapiens]
[Reaction:8852019] MET bound PI3K generates PIP3 [Homo sapiens]
[Reaction:9846380] GOCAM GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens]
[Reaction:9846385] GOCAM PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens] |
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