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Details on Person EGF [extracellular region]

Class:Id	EntityWithAccessionedSequence:179863
_displayName	EGF [extracellular region]
_timestamp	2013-07-29 20:44:39
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
endCoordinate	1023
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:4084591] Orlic-Milacic, M, 2013-07-29
name	EGF Epidermal Growth Factor
referenceEntity	[ReferenceGeneProduct:54210] UniProt:P01133 EGF [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362268] R-HSA-179863.1
startCoordinate	971
(hasComponent)	[Complex:179847] EGF:EGFR [plasma membrane] [Homo sapiens] [Complex:179860] EGF:Phospho-EGFR [plasma membrane] [Homo sapiens] [Complex:179891] EGF:Phospho-EGFR (SRC) [plasma membrane] [Homo sapiens] [Complex:182911] EGF:Phospho-EGFR (Y1045) dimer [plasma membrane] [Homo sapiens] [Complex:182941] EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:EPS15:Clathrin [plasma membrane] [Homo sapiens] [Complex:182943] EGF:p-6Y-EGFR:CBL:CIN85 [plasma membrane] [Homo sapiens] [Complex:1220573] EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1220580] EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1248702] EGF:p-6Y-EGFR [plasma membrane] [Homo sapiens] [Complex:1809164] EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] [Homo sapiens] List all 12 refering instances
(hasMember)	[DefinedSet:9624194] EGF-like ligands [extracellular region] [Homo sapiens]
(input)	[Reaction:1220612] Binding of EGF to ligand-responsive EGFR mutants [Homo sapiens] [FailedReaction:5638137] EGFRvIII cancer variant does not bind EGF ligand [Homo sapiens]
(output)	[Reaction:177946] Pro-EGF is cleaved to form mature EGF [Homo sapiens] [BlackBoxEvent:9796044] NFE2L2 dependent EGF expression [Homo sapiens] [Reaction:9846368] GOCAM Pro-EGF is cleaved to form mature EGF [Homo sapiens]
(regulator)	[PositiveRegulation:9725602] Positive regulation by 'EGF [extracellular region]' [NegativeRegulation:9989080] Negative regulation by 'EGF [extracellular region]'
(updatedInstance)	[_UpdateTracker:9882235] Update Tracker - [EntityWithAccessionedSequence:179863] EGF [extracellular region] - v45:[addName] [_UpdateTracker:9888602] Update Tracker - [EntityWithAccessionedSequence:179863] EGF [extracellular region] - v46:[removeName]
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No pathways have been reviewed or authored by EGF [extracellular region] (179863)