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Details on Person PI(4,5)P2 [plasma membrane]

Class:IdSimpleEntity:179856
_displayNamePI(4,5)P2 [plasma membrane]
_timestamp2022-01-05 20:15:37
compartment[Compartment:876] plasma membrane
created[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
crossReference[DatabaseIdentifier:36380] COMPOUND:C04637
modified[InstanceEdit:188419] Jassal, Bijay, 2006-10-12
[InstanceEdit:212462] Jassal, B, 2008-02-11 14:13:21
[InstanceEdit:1368195] Orlic-Milacic, Marija, 2011-06-30
[InstanceEdit:1472109] Garapati, P V, 2011-08-03
[InstanceEdit:1629729] Williams, MG, 2011-10-03
[InstanceEdit:9616752] Shorser, Solomon, 2018-08-13
[InstanceEdit:9619952] Wu, G, 2018-09-19
[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05
namePI(4,5)P2
PIP2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Phosphatidylinositol-4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
referenceEntity[ReferenceMolecule:9760917] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [ChEBI:58456]
stableIdentifier[StableIdentifier:365664] R-ALL-179856.4
(activeUnit)[NegativeRegulation:8874423] Negative regulation by 'VAV family:PIP2 [plasma membrane]'
(hasComponent)[Complex:202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Homo sapiens]
[Complex:202990] TOCA-1:(Cdc42-GTP):PIP2:N-WASP:WIP complex [plasma membrane] [Homo sapiens]
[Complex:202999] GRB2:(Cdc42:GTP):PIP2:WIP:N-WASP complex [plasma membrane] [Homo sapiens]
[Complex:203002] NCK1:PIP2:N-WASP:WIP complex [plasma membrane] [Homo sapiens]
[Complex:203039] WIP:N-WASP:PIP2:Cdc42-GTP complex [plasma membrane] [Homo sapiens]
[Complex:354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Homo sapiens]
[Complex:354132] Vinculin bound to PIP2 [plasma membrane] [Homo sapiens]
[Complex:374558] p-T567-EZR:PIP2 [plasma membrane] [Homo sapiens]
[Complex:374570] EZR:PIP2 [plasma membrane] [Homo sapiens]
[Complex:398207] ECM:Integrin receptor cluster:FAK56D:SRC:RHEA dimer:VINC:F-actin:ACTN:ZASP:BY:PAX:WECH:CG32528:ILK:STCK:ICS:FIT:Phospho PIP5K59B:PIP2 [plasma membrane] [Drosophila melanogaster]
List all 47 refering instances
(hasMember)[DefinedSet:5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
[DefinedSet:8874460] PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
(input)[Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Homo sapiens]
[Reaction:110453] Phosphorylation of PIP2 to PIP3 by Dp110 [Drosophila melanogaster]
[Reaction:111879] PIP2 hydrolysis [Homo sapiens]
[Reaction:112090] AGE-1 mediated phosphorylation of PIP2 to PIP3 [Caenorhabditis elegans]
[Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens]
[Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens]
[Reaction:177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Homo sapiens]
[Reaction:182061] Active Plcg1 hydrolyses PIP2 [Rattus norvegicus]
[Reaction:186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens]
[BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens]
List all 105 refering instances
(output)[Reaction:110459] PIP3 dephosphorylated to PIP2 by DPTEN [Drosophila melanogaster]
[Reaction:112095] DAF-18 mediated dephosphorylation of PIP3 to PIP2 [Caenorhabditis elegans]
[Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens]
[Reaction:377065] PTEN dephosphorylates PIP3 to PIP2 [Drosophila melanogaster]
[Reaction:443866] PIP5K1 converts PI(4)P to PI(4,5)P2 [Homo sapiens]
[Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens]
[Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens]
[Reaction:3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Homo sapiens]
[Reaction:8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Homo sapiens]
(regulator)[PositiveRegulation:420613] Positive regulation by 'PI(4,5)P2 [plasma membrane]'
[PositiveRegulation:420614] Positive regulation by 'PI(4,5)P2 [plasma membrane]'
(replacementInstances)[_Deleted:9026186] Deletion of instance: 36379
(updatedInstance)[_UpdateTracker:9866592] Update Tracker - [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] - v24:[addName]
[_UpdateTracker:9871258] Update Tracker - [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] - v39:[addName]
[_UpdateTracker:9892068] Update Tracker - [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] - v52:[addName]
[_UpdateTracker:9903235] Update Tracker - [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] - v80:[add_removeReferenceEntity]
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No pathways have been reviewed or authored by PI(4,5)P2 [plasma membrane] (179856)
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