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Details on Person EGFR [plasma membrane]

Class:Id	EntityWithAccessionedSequence:179837
_displayName	EGFR [plasma membrane]
_timestamp	2008-06-20 12:56:10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
endCoordinate	1210
name	EGFR Epidermal Growth Factor Receptor
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:370307] R-HSA-179837.1
startCoordinate	25
(activeUnit)	[CatalystActivity:179804] protein tyrosine kinase activity of EGF:EGFR dimer [plasma membrane] [CatalystActivity:182979] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] [CatalystActivity:183047] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [CatalystActivity:8867039] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [CatalystActivity:9624430] protein tyrosine kinase activity of EGF-like ligands:EGFR dimer [plasma membrane] [CatalystActivity:9624433] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] [CatalystActivity:9851165] epidermal growth factor receptor activity of EGFR:EGF-like ligands [plasma membrane] [CatalystActivity:9851168] epidermal growth factor receptor activity of EGF-like ligands:EGFR dimer [plasma membrane]
(entityOnOtherCell)	[Reaction:445069] L1-EGFR trans-heterodimerization [Homo sapiens] [Complex:445016] L1-EGFR trans-heterodimer [plasma membrane] [Homo sapiens]
(hasCandidate)	[CandidateSet:9837684] (EGFR,IGF1R) [plasma membrane] [Homo sapiens]
(hasComponent)	[Complex:179847] EGF:EGFR [plasma membrane] [Homo sapiens] [Complex:204230] ALCAM bound to EGFR [plasma membrane] [Homo sapiens] [Complex:373671] LRIG1:EGFR complex [plasma membrane] [Homo sapiens] [Complex:445016] L1-EGFR trans-heterodimer [plasma membrane] [Homo sapiens] [Complex:1248675] EGFR:Cetuximab [plasma membrane] [Homo sapiens] [Complex:8857547] HBEGF:EGFR [plasma membrane] [Homo sapiens] [Complex:9603649] EGFR:EGFR [plasma membrane] [Homo sapiens] [Complex:9624419] EGFR:EGF-like ligands [plasma membrane] [Homo sapiens] [Complex:9674862] EGFR:AAMP [plasma membrane] [Homo sapiens] [Complex:9851427] EGFR:FAM83B,(FAM83A, FAM83D) [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:9610864] HCMV Host Cell Receptors [plasma membrane] [Homo sapiens]
(input)	[Reaction:177942] EGFR binds EGF ligand [Homo sapiens] [Reaction:204235] ALCAM binds EGFR [Homo sapiens] [Reaction:373718] LRIG1 binds EGFR [Homo sapiens] [Reaction:445069] L1-EGFR trans-heterodimerization [Homo sapiens] [Reaction:1248677] Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody [Homo sapiens] [BlackBoxEvent:2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor [Homo sapiens] [Reaction:9674531] AAMP binds EGFR [Homo sapiens] [Reaction:9846408] GOCAM EGFR binds EGF ligand [Homo sapiens] [Reaction:9846415] GOCAM AAMP binds EGFR [Homo sapiens] [Reaction:9851407] FAM83B, (FAM83A, FAM83D) bind EGFR [Homo sapiens]
(marker)	[MarkerReference:9946686] EGFR [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue
(normalEntity)	[EntityFunctionalStatus:5637721] gain_of_function of Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:5638136] loss_of_function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]
(output)	[BlackBoxEvent:8874797] EGFR gene expression is stimulated by TFAP2C [Homo sapiens] [BlackBoxEvent:9639547] Expression of EGFR regulated by NR3C2 [Homo sapiens]
(proteinMarker)	[Cell:9925876] mammary myoepithelial progenitor cell [Homo sapiens]
(requiredInputComponent)	[CellDevelopmentStep:9725621] Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis [Homo sapiens]
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No pathways have been reviewed or authored by EGFR [plasma membrane] (179837)