Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person Ligands of the epidermal growth factor receptor (EGFR) are ...
| Class:Id | Summation:179818 |
|---|---|
| _displayName | Ligands of the epidermal growth factor receptor (EGFR) are ... |
| _timestamp | 2008-02-11 14:13:29 |
| created | [InstanceEdit:179808] Jassal, Bijay, 2006-05-09 |
| modified | [InstanceEdit:212462] Jassal, B, 2008-02-11 14:13:21 |
| text | Ligands of the epidermal growth factor receptor (EGFR) are shed from the plasma membrane by metalloproteases. Identification of the sheddases for EGFR ligands using mouse embryonic cells lacking candidate sheddases (a disintegrin and metalloprotease; ADAM) has revealed that ADAM10, -12 and -17 are the sheddases of the EGFR ligands in response to various shedding stimulants such as GPCR agonists, growth factors, cytokines, osmotic stress, wounding and phorbol ester. Among the EGFR ligands, heparin-binding EGF-like growth factor (HB-EGF), EGF and TGF-alpha are the best characterized. |
| (summation) | [Reaction:177946] Pro-EGF is cleaved to form mature EGF [Homo sapiens] [Reaction:179883] Mouse pro-EGF is cleaved by ADAM sheddases [Mus musculus] [Reaction:9846368] GOCAM Pro-EGF is cleaved to form mature EGF [Homo sapiens] |
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No pathways have been reviewed or authored by Ligands of the epidermal growth factor receptor (EGFR) are ... (179818)
