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Details on Person Degradation of multiubiquitinated Nek2A

Class:Id	BlackBoxEvent:179421
_displayName	Degradation of multiubiquitinated Nek2A
_doRelease	TRUE
_timestamp	2016-11-10 00:55:10
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:179418] Matthews, L, 2006-04-28 10:05:01
edited	[InstanceEdit:182446] Matthews, L, 2006-07-10 14:28:40
input	[Complex:179414] Multiubiquitinated Nek2A [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:179423] APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box [LiteratureReference:182609] Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
modified	[InstanceEdit:182612] Matthews, L, 2006-07-11 10:29:13 [InstanceEdit:182667] Matthews, L, 2006-07-11 21:24:12 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Degradation of multiubiquitinated Nek2A
output	[Complex:141410] MCC:APC/C complex [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:179417] Multiubiquitination of Nek2A [Homo sapiens] [Reaction:179410] Association of Nek2A with MCC:APC/C [Homo sapiens]
releaseDate	2006-08-02
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361900] R-HSA-179421.3
summation	[Summation:182613] Nek2A is degraded by the 26S proteasome following ubiquityla...
(hasEvent)	[Pathway:179409] APC-Cdc20 mediated degradation of Nek2A [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764088] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764089] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764093] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764095] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764114] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764137] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764144] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764145] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764146] Futile Cycle: Degradation of multiubiquitinated Nek2A
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