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Details on Person Multiubiquitination of Nek2A

Class:IdReaction:179417
_displayNameMultiubiquitination of Nek2A
_doReleaseTRUE
_timestamp2022-02-08 22:35:14
authored[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity[CatalystActivity:179412] ubiquitin-protein transferase activity of Nek2A:MCC:APC/C complex [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:179418] Matthews, L, 2006-04-28 10:05:01
edited[InstanceEdit:182446] Matthews, L, 2006-07-10 14:28:40
input[Complex:179413] Nek2A:MCC:APC/C complex [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:179423] APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
modified[InstanceEdit:182614] Matthews, L, 2006-07-11 10:29:29
[InstanceEdit:182668] Matthews, L, 2006-07-11 21:24:37
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9764086] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764098] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764110] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764118] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMultiubiquitination of Nek2A
negativePrecedingEvent[NegativePrecedingEvent:9764083] Futile Cycle: Degradation multiubiquitinated Cyclin A
[NegativePrecedingEvent:9764087] Futile Cycle: Degradation of multiubiquitinated Cyclin B
[NegativePrecedingEvent:9764088] Futile Cycle: Degradation of multiubiquitinated Nek2A
[NegativePrecedingEvent:9764102] Futile Cycle: Degradation of multiubiquitinated Securin
[NegativePrecedingEvent:9764101] Futile Cycle: Degradation of multiubiquitinated cell cycle proteins
[NegativePrecedingEvent:9764115] Futile Cycle: SCF-mediated degradation of Emi1
output[Complex:179414] Multiubiquitinated Nek2A [cytosol] [Homo sapiens]
precedingEvent
releaseDate2006-08-02
reviewed[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358307] R-HSA-179417.4
summation[Summation:182615] Nek2A is ubiquitinated by the APC/C-Cdc20 ubiquitin ligase.
(hasEvent)[Pathway:179409] APC-Cdc20 mediated degradation of Nek2A [Homo sapiens]
(precedingEvent)[BlackBoxEvent:179421] Degradation of multiubiquitinated Nek2A [Homo sapiens]
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